Article
Both replication bypass fidelity and repair efficiency influence the yield of mutations per target dose in intact mammalian cells induced by benzo[a]pyrene-diol-epoxide and dibenzo[a,l]pyrene-diol-epoxide.
DNA repair - 2 Aug 2008
Lagerqvist Anne, Håkansson Daniel, Prochazka Gabriela, Lundin Cecilia, Dreij Kristian, Segerbäck Dan, Jernström Bengt, Törnqvist Margareta, Seidel Albrecht, Erixon Klaus, Jenssen Dag
Abstract excerpt
Mutations induced by polycyclic aromatic hydrocarbons (PAH) are expected to be produced when error-prone DNA replication occurs across unrepaired DNA lesions formed by reactive PAH metabolites such as diol epoxides. The mutagenicity of the two PAH-diol epoxides (+)-anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE) and...
Topics
- 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
- Animals
- Benzopyrenes
- Cell Line
- Chromatography, Thin Layer
- Cricetinae
- Cricetulus
- DNA Repair
- DNA Replication
- Dose-Response Relationship, Drug