Article
Low absolute mutagenic efficiency but high cytotoxicity of a non-bay region diol epoxide derived from benzo[a]pyrene.
Mutation research - 1 Dec 1991
MacLeod M C, Adair G, Daylong A, Lew L, Humphrey R M
Abstract excerpt
Insights into the mechanisms of chemical carcinogenesis can sometimes be gained by comparing the effects of closely related chemicals which differ in carcinogenic potency. We have treated Chinese hamster ovary (CHO) cells with a non-carcinogenic metabolite of benzo[a]pyrene, 9r,10t-dihydroxy-7c,8...
Topics
- 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
- Adenine Phosphoribosyltransferase
- Animals
- Benzopyrenes
- CHO Cells
- Carcinogenicity Tests
- Cell Survival
- Cricetinae
- DNA
- DNA Adducts
- DNA Repair
- Epoxy Compounds
- Fluorescence
- Hypoxanthine Phosphoribosyltransferase
- Kinetics
- Mutagenesis
- Mutagenicity Tests
- Mutation