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DNA repair and replication influence the number of mutations per adduct of polycyclic aromatic hydrocarbons in mammalian cells.

DNA repair - 15 Aug 2011

Lagerqvist Anne, Håkansson Daniel, Lundin Cecilia, Prochazka Gabriela, Dreij Kristian, Segerbäck Dan, Jernström Bengt, Törnqvist Margareta, Frank Heinz, Seidel Albrecht, Erixon Klaus, Jenssen Dag

Abstract excerpt

Polycyclic aromatic hydrocarbons (PAH) are an important class of environmental contaminants many of which require metabolic activation to DNA-reactive bay or fjord region diolepoxides (DE) in order to exert their mutagenic and carcinogenic effects. In this study, the mutagenicity of the bay region diolepoxides (+)-anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE) and...

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PMID: 21727035
DOI: 10.1016/j.dnarep.2011.06.002

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PAH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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