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Article

Establishment of a lymphoblastoid cell line, SD-1, expressing the p190 bcr-abl chimaeric protein.

Leukemia - 1 Jan 1991

Dhut S, Gibbons B, Chaplin T, Young B D

Abstract excerpt

A lymphoblastoid cell line (SD-1) has been established by Epstein-Barr virus immortalisation of Philadelphia chromosome positive acute lymphoblastic leukaemia (ALL) cells. Using newly derived anti-bcr monoclonal and anti-abl polyclonal antibodies it was demonstrated that both the original leukaemic cells and the derived cell line expressed the p190 form of the bcr-abl protein found in a proportion of cases of...

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PMID: 1847983

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Establishment of a lymphoblastoid cell line, SD-1, expressing the p190 bcr-abl chimaeric protein.PMID 1847983Read ↗

A BCR-ABLp190 Fusion Gene Made by Homologous Recombination Causes B-Cell Acute Lymphoblastic Leukemias in Chimeric Mice With Independence of the Endogenous bcr ProductSemantic proximity Read ↗

The 5' non-coding region of the BCR/ABL oncogene augments its ability to stimulate the growth of immature lymphoid cells.Semantic proximity Read ↗

BCR/ABL genes and leukemic phenotype: from molecular mechanisms to clinical correlations.Semantic proximity Read ↗

Tumorigenic activity of the BCR-ABL oncogenes is mediated by BCL2.Semantic proximity Read ↗

The P190, P210, and P230 Forms of the <i>BCR/ABL</i> Oncogene Induce a Similar Chronic Myeloid Leukemia–like Syndrome in Mice but Have Different Lymphoid Leukemogenic ActivitySemantic proximity Read ↗

A new Ph1+, bcr cell line derived from a patient with ALL-L1 gained autonomy in culture concomitant to CD23 expression.Semantic proximity Read ↗

BCR/ABL P210 and P190 cause distinct leukemia in transgenic miceSemantic proximity Read ↗

Sustained leukaemic phenotype after inactivation of BCR-ABLp190 in mice.Semantic proximity Read ↗

Consistent involvement of the bcr gene by 9;22 breakpoints in pediatric acute leukemiasSemantic proximity Read ↗

BCR/ABL P190 transgenic mice develop leukemia in the absence of Crkl.Semantic proximity Read ↗

The Dbl homology domain of BCR is not a simple spacer in P210BCR-ABL of the Philadelphia chromosome.Semantic proximity Read ↗

Mutant p53 detected in a majority of Burkitt lymphoma cell lines by monoclonal antibody PAb240.Semantic proximity Read ↗

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