Establishment of a lymphoblastoid cell line, SD-1, expressing the p190 bcr-abl chimaeric protein.

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Article

Establishment of a lymphoblastoid cell line, SD-1, expressing the p190 bcr-abl chimaeric protein.

Leukemia - 1 Jan 1991

Dhut S, Gibbons B, Chaplin T, Young B D

Abstract excerpt

A lymphoblastoid cell line (SD-1) has been established by Epstein-Barr virus immortalisation of Philadelphia chromosome positive acute lymphoblastic leukaemia (ALL) cells. Using newly derived anti-bcr monoclonal and anti-abl polyclonal antibodies it was demonstrated that both the original leukaemic cells and the derived cell line expressed the p190 form of the bcr-abl protein found in a proportion of cases of...

Topics

Animals
Antigens, Differentiation
Antigens, Neoplasm
Cell Transformation, Viral
DNA, Neoplasm
Fusion Proteins, bcr-abl
HLA-DR Antigens
Herpesvirus 4, Human
Humans
Mice
Mice, Nude

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Transplantation

Neprilysin

Phenotype

Philadelphia Chromosome

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 1847983

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1847983-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Establishment of a lymphoblastoid cell line, SD-1, expressing the p190 bcr-abl chimaeric protein.PMID 1847983Read ↗

A BCR-ABLp190 Fusion Gene Made by Homologous Recombination Causes B-Cell Acute Lymphoblastic Leukemias in Chimeric Mice With Independence of the Endogenous bcr ProductSemantic proximity Read ↗

The 5' non-coding region of the BCR/ABL oncogene augments its ability to stimulate the growth of immature lymphoid cells.Semantic proximity Read ↗

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The P190, P210, and P230 Forms of the <i>BCR/ABL</i> Oncogene Induce a Similar Chronic Myeloid Leukemia–like Syndrome in Mice but Have Different Lymphoid Leukemogenic ActivitySemantic proximity Read ↗

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