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Article

BCR/ABL P190 transgenic mice develop leukemia in the absence of Crkl.

Oncogene - 9 May 2002

Hemmeryckx Bianca, Reichert Anja, Watanabe Meguru, Kaartinen Vesa, de Jong Ron, Pattengale Paul K, Groffen John, Heisterkamp Nora

Abstract excerpt

The Bcr/Abl fusion protein directly causes chronic myelogenous leukemia and Philadelphia-chromosome positive acute lymphoblastic leukemia. Multiple independent studies have implicated Crkl, a small adapter protein, in transduction of oncogenic signals of Bcr/Abl and Crkl tyrosine-phosphorylation is used as a diagnostic tool for Philadelphia-positive leukemia. To evaluate the contribution of Crkl to this type of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12082638
DOI: 10.1038/sj.onc.1205452

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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BCR/ABL P190 transgenic mice develop leukemia in the absence of Crkl.PMID 12082638Read ↗

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A BCR-ABLp190 Fusion Gene Made by Homologous Recombination Causes B-Cell Acute Lymphoblastic Leukemias in Chimeric Mice With Independence of the Endogenous bcr ProductSemantic proximity Read ↗

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p130CAS Forms a Signaling Complex with the Adapter Protein CRKL in Hematopoietic Cells Transformed by the BCR/ABL OncogeneSemantic proximity Read ↗

The CRKL Adaptor Protein Transforms Fibroblasts and Functions in Transformation by the BCR-ABL OncogeneSemantic proximity Read ↗

Crk and CrkL as Therapeutic Targets for Cancer TreatmentSemantic proximity Read ↗

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The P190, P210, and P230 Forms of the <i>BCR/ABL</i> Oncogene Induce a Similar Chronic Myeloid Leukemia–like Syndrome in Mice but Have Different Lymphoid Leukemogenic ActivitySemantic proximity Read ↗

BCR/ABL P210 and P190 cause distinct leukemia in transgenic miceSemantic proximity Read ↗

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