A new Ph1+, bcr cell line derived from a patient with ALL-L1 gained autonomy in culture concomitant to CD23 expression.

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Article

A new Ph1+, bcr cell line derived from a patient with ALL-L1 gained autonomy in culture concomitant to CD23 expression.

Leukemia - 1 May 1990

Grausz D, Lanotte M, Valensi F, Hillion J, Chen S J, Chen Z, Morinet F, Berger R

Abstract excerpt

A permanent cell line, LEF1, has been established from the cells of an adult suffering from a Philadelphia positive acute lymphoblastic leukemia. The LEF1 cell line was obtained by maintaining peripheral blood cells from the patient in culture on a fibroblast feeder; subsequently, an autonomously growing cell population, independent of that feeder layer, developed. The karyotype of the cell line, 46,...

Topics

Adult
Antigens, CD
Antigens, Differentiation, B-Lymphocyte
Blotting, Northern
Blotting, Southern
Cell Division
Female
Flow Cytometry
Humans
Oncogenes
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Philadelphia Chromosome

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Receptors, Fc

Receptors, IgE

Restriction Mapping

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 2143794

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2143794-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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