The Dbl homology domain of BCR is not a simple spacer in P210BCR-ABL of the Philadelphia chromosome.

doi:10.1074/jbc.M105484200

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Article

The Dbl homology domain of BCR is not a simple spacer in P210BCR-ABL of the Philadelphia chromosome.

The Journal of biological chemistry - 19 Oct 2001

Kin Y, Li G, Shibuya M, Maru Y

Abstract excerpt

The Dbl homology (DH) domain of BCR in P210BCR-ABL (P210/WT) has been thought to have a negative effect on the activation of BCR-ABL because P185BCR-ABL, in which this region is physically deleted, has stronger biochemical and biological activities. To study the role of the DH domain of BCR in the background of P210/WT, the region was replaced with homologous sequences derived from Dbl (P210/Dbl) or CDC24...

Topics

Animals
Apoptosis
Bone Marrow Cells
Cell Line
Fusion Proteins, bcr-abl
Gene Deletion
Guanine Nucleotide Exchange Factors
Lac Operon
Luciferases
Mice
Mutation
Philadelphia Chromosome
Phosphorylation
Protein Binding
Protein Structure, Tertiary
Proto-Oncogene Proteins
Rats
Time Factors

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PMID: 11502748
DOI: 10.1074/jbc.M105484200

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