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Article

Sustained leukaemic phenotype after inactivation of BCR-ABLp190 in mice.

Oncogene - 15 Mar 2007

Pérez-Caro M, Gutierrez-Cianca N, González-Herrero I, López-Hernández I, Flores T, Orfao A, Sánchez-Martín M, Gutiérrez-Adán A, Pintado B, Sánchez-García I

Abstract excerpt

Pharmacological inactivation of cancer genes or products is being used as a strategy for therapy in oncology. To investigate the potential role of BCR-ABLp190 cessation in leukaemia development, we generated mice carrying a tetracycline-repressible BCR-ABLp190 transgene. These mice were morphologically normal at birth, and developed leukaemias. Disease was characterized by the presence of B-cell blasts...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16983340
DOI: 10.1038/sj.onc.1209968

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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