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Effects of ribavirin on the replication and genetic stability of porcine reproductive and respiratory syndrome virus

6 Feb 2015

Abstract excerpt

BACKGROUND: Although modified live virus (MLV) vaccines are commonly used for porcine reproductive and respiratory syndrome virus (PRRSV) control, there have been safety concerns due to the quick reversion of MLV to virulence during replication in pigs. Previous studies have demonstrated that mutant viruses emerged from lethal mutagenesis driven by antiviral mutagens and that those viruses had higher genetic...

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PMID: 25890207
DOI: 10.1186/s12917-015-0330-z

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