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Article

Cidofovir resistance in vaccinia virus is linked to diminished virulence in mice.

Journal of virology - 1 Oct 2006

Andrei Graciela, Gammon Don B, Fiten Pierre, De Clercq Erik, Opdenakker Ghislain, Snoeck Robert, Evans David H

Abstract excerpt

Cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC)] is recognized as a promising drug for the treatment of poxvirus infections, but drug resistance can arise by a mechanism that is poorly understood. We show here that in vitro selection for high levels of resistance to HPMPC produces viruses encoding two substitution mutations in the virus DNA polymerase (E9L) gene. These mutations are located...

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Identifiers

PMID: 16973545
DOI: 10.1128/JVI.00605-06
PMCID: PMC1617232

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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