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Article

Small changes in lymphocyte development and activation in mice through tissue-specific alteration of heparan sulphate.

Immunology - 1 Nov 2008

Garner Omai B, Yamaguchi Yu, Esko Jeffrey D, Videm Vibeke

Abstract excerpt

We have examined the role of heparan sulphate in lymphocyte development and activation in mice by conditionally deleting the genes encoding the heparan sulphate biosynthetic enzymes N-deacetylase/N-sulphotransferase-1 and -2 (Ndst1 and Ndst2) and glucuronic acid/N-acetylglucosamine co-polymerase-1 (Ext1) in T cells and B cells, respectively. Ndst1 and Ndst2 are the only Ndst isoforms in T cells. In T-cell...

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Identifiers

PMID: 18479348
DOI: 10.1111/j.1365-2567.2008.02856.x
PMCID: PMC2669145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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