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Article

Altered heparan sulfate structure in mice with deleted NDST3 gene function.

The Journal of biological chemistry - 13 Jun 2008

Pallerla Srinivas R, Lawrence Roger, Lewejohann Lars, Pan Yi, Fischer Tobias, Schlomann Uwe, Zhang Xin, Esko Jeffrey D, Grobe Kay

Abstract excerpt

We report the generation and analysis of mutant mice bearing a targeted disruption of the heparan sulfate (HS)-modifying enzyme GlcNAc N-deacetylase/N-sulfotransferase 3 (NDST3). NDST3(-/-) mice develop normally, are fertile, and show only subtle hematological and behavioral abnormalities in agreement with only moderate HS undersulfation. Compound mutant mice made deficient in NDST2;NDST3 activities also develop...

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Share to Gene Deletion
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18385133
DOI: 10.1074/jbc.M709774200
PMCID: PMC2423263

Genes

NDST3
NDST1
NDST2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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