Article
Glycotranscriptome study reveals an enzymatic switch modulating glycosaminoglycan synthesis during B-cell development and activation.
European journal of immunology - 1 Dec 2011
Duchez Sophie, Pascal Virginie, Cogné Nadine, Jayat-Vignoles Chantal, Julien Raymond, Cogné Michel
Abstract excerpt
B-cell fate and responses are modulated by soluble mediators and direct cellular interactions. Migration properties also vary during differentiation, commitment and activation. In many cells, modulation of responses to stimuli involves cell surface glycans, whose architecture depends on the simultaneous expression of multiple enzymes. By looking at the glycosylation-related gene expression patterns among B-cell...
Topics
- Animals
- B-Lymphocytes
- Cell Differentiation
- Cell Line
- Cell Line, Tumor
- Chondroitin Sulfates
- Genetic Variation
- Glycosaminoglycans
- Heparitin Sulfate
- Immunoglobulins
- Lymphocyte Activation
- Mice
- Mice, Inbred C57BL