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Article

Alpha-endosulfine, a positional and functional candidate gene for type 2 diabetes: molecular screening, association studies, and role in reduced insulin secretion.

Molecular genetics and metabolism - 1 Jan 2004

Wang Hua, Craig Rebekah L, Schay John, Chu Winston, Das Swapan K, Zhang Zhengxian, Elbein Steven C

Abstract excerpt

Impaired glucose stimulated insulin secretion is a prominent, early defect in type 2 diabetes. Insulin secretion is coupled to glucose metabolism by effects of the intracellular ATP/ADP ratio on the multimeric beta-cell potassium channel. The sulfonylurea receptor (SUR1 or ABCC8), the regulatory...

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Source

Identifiers

PMID: 14728986
DOI: 10.1016/j.ymgme.2003.08.003

Genes

ENSA
ABCC8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14728986-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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