Article
Alpha-endosulfine, a positional and functional candidate gene for type 2 diabetes: molecular screening, association studies, and role in reduced insulin secretion.
Molecular genetics and metabolism - 1 Jan 2004
Wang Hua, Craig Rebekah L, Schay John, Chu Winston, Das Swapan K, Zhang Zhengxian, Elbein Steven C
Abstract excerpt
Impaired glucose stimulated insulin secretion is a prominent, early defect in type 2 diabetes. Insulin secretion is coupled to glucose metabolism by effects of the intracellular ATP/ADP ratio on the multimeric beta-cell potassium channel. The sulfonylurea receptor (SUR1 or ABCC8), the regulatory subunit of that channel, binds sulfonylurea agents and thus closes the channel and stimulates exocytosis of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.