Article
Increased expression of Smad6 deteriorates murine acute experimental pancreatitis in two models.
Gut - 1 Jun 2008
Nakamura H, Tashiro M, Asaumi H, Nomiyama Y, Kaku M, Watanabe S, Miyamoto T, Otsuki M
Abstract excerpt
BACKGROUND: Smad6 is implicated in the inhibition of bone morphogenetic protein signalling. However, the function of Smad6 in the pancreas remains obscure. METHODS: To elucidate the unknown function of Smad6, we developed transgenic mice selectively expressing Smad6 in pancreatic acinar cells usi...
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