Article
Requirements for bypass of UV-induced lesions in single-stranded DNA of bacteriophage phi X174 in Salmonella typhimurium.
Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 1991
Slater S C, Maurer R
Abstract excerpt
According to the current model for mutagenic bypass of UV-induced lesions, efficient bypass requires three proteins: activated RecA (RecA*) and either activated UmuD (UmuD') and UmuC or their plasmid-encoded analogues, MucA' and MucB. RecA* aids synthesis of UmuD' and UmuC (and MucA'/MucB) at two levels: by inactivation of the LexA transcriptional repressor of these genes and by cleavage of UmuD (and MucA) to...
Topics
- Bacterial Proteins
- Bacteriophage phi X 174
- DNA, Single-Stranded
- Dose-Response Relationship, Radiation
- Genotype
- Plasmids
- Rec A Recombinases
- Salmonella typhimurium
- Ultraviolet Rays