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Article

The MODY1 gene for hepatocyte nuclear factor 4alpha and a feedback loop control COUP-TFII expression in pancreatic beta cells.

Molecular and cellular biology - 1 Jul 2008

Perilhou Anaïs, Tourrel-Cuzin Cécile, Zhang Pili, Kharroubi Ilham, Wang Haiyan, Fauveau Véronique, Scott Donald K, Wollheim Claes B, Vasseur-Cognet Mireille

Abstract excerpt

Pancreatic islet beta cell differentiation and function are dependent upon a group of transcription factors that maintain the expression of key genes and suppress others. Knockout mice with the heterozygous deletion of the gene for chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) or the complete disruption of the gene for hepatocyte nuclear factor 4alpha (HNF4alpha) in pancreatic beta cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18474611
DOI: 10.1128/MCB.01191-07
PMCID: PMC2447131

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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