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Article

Activation of the insulin gene promoter through a direct effect of hepatocyte nuclear factor 4 alpha.

The Journal of biological chemistry - 19 Jul 2002

Bartoov-Shifman Reut, Hertz Rachel, Wang Haiyan, Wollheim Claes B, Bar-Tana Jacob, Walker Michael D

Abstract excerpt

Maturity onset diabetes of the young, subtype 1 (MODY1), is associated with defective glucose-dependent insulin secretion from pancreatic beta cells. MODY1 is caused by mutation in the transcription factor hepatocyte nuclear factor 4 alpha (HNF4 alpha). To understand better the MODY1 phenotype, we tested whether HNF4 alpha was able to modulate directly the insulin gene promoter. Transfection of cultured 293T...

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PMID: 11994285
DOI: 10.1074/jbc.M201582200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Activation of the insulin gene promoter through a direct effect of hepatocyte nuclear factor 4 alpha.PMID 11994285Read ↗

Human insulin gene is a target gene of hepatocyte nuclear factor-1alpha (HNF-1alpha) and HNF-1beta.Semantic proximity Read ↗

Naturally occurring mutations in the human HNF4alpha gene impair the function of the transcription factor to a varying degreeSemantic proximity Read ↗

A missense mutation in hepatocyte nuclear factor-4 alpha, resulting in a reduced transactivation activity, in human late-onset non-insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function.Semantic proximity Read ↗

HNF-4alpha: from MODY to late-onset type 2 diabetes.Semantic proximity Read ↗

Identification of seven novel nucleotide variants in the hepatocyte nuclear factor-1alpha (TCF1) promoter region in MODY patients.Semantic proximity Read ↗

A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young.Semantic proximity Read ↗

Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)Semantic proximity Read ↗

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Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)Semantic proximity Read ↗

The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism.Semantic proximity Read ↗

Molecular mechanism of HNF-1A–mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetesSemantic proximity Read ↗

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