Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Genetic Switch in Pancreatic β-Cells

1 Aug 2002

Abstract excerpt

Heterozygous mutations in the genes encoding transcriptional regulators hepatocyte nuclear factor (HNF)-1alpha and HNF-4alpha cause a form of diabetes known as maturity-onset diabetes of the young (MODY). Haploinsufficiency of HNF-1alpha or HNF-4alpha results in MODY because of defective function of pancreatic islet cells. In contrast, homozygous null mutations in mouse models lead to widespread and profound gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes and associated disorders
Share to Diabetes Management and Research
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12145145
DOI: 10.2337/diabetes.51.8.2355

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Genetic Switch in Pancreatic β-CellsPMID 12145145Read ↗

HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetesSemantic proximity Read ↗

Distinct roles of HNF1beta, HNF1alpha, and HNF4alpha in regulating pancreas development, beta-cell function and growth.Semantic proximity Read ↗

Regulation of pancreatic beta-cell function by the HNF transcription network: lessons from maturity-onset diabetes of the young (MODY).Semantic proximity Read ↗

A transcription factor regulatory circuit in differentiated pancreatic cells.Semantic proximity Read ↗

Roles of HNF1α and HNF4α in pancreatic β-cells: lessons from a monogenic form of diabetes (MODY).Semantic proximity Read ↗

Epistasis of Transcriptomes Reveals Synergism between Transcriptional Activators Hnf1α and Hnf4αSemantic proximity Read ↗

Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta.Semantic proximity Read ↗

Regulation of a transcription factor network required for differentiation and metabolism.Semantic proximity Read ↗

Heterozygous Hnf1a Mutation in Mice Reveals Multiple Pathogenic Mechanisms of HNF1A-MODYSemantic proximity Read ↗

HNF1α transcriptional activation and repression maintain human islet α and β cell functionSemantic proximity Read ↗

Transcriptional Regulation of X-Box-binding Protein One (XBP1) by Hepatocyte Nuclear Factor 4α (HNF4Α) Is Vital to Beta-cell FunctionSemantic proximity Read ↗

Exploring the role of the HNF-1αG319S polymorphism in β cell failure and youth-onset type 2 diabetes: Lessons from MODY and Hnf-1α-deficient animal models.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.