Article
SUMO-mediated regulation of NLRP3 modulates inflammasome activity.
Nature communications - 1 Aug 2018
Barry Rachael, John Sidonie Wicky, Liccardi Gianmaria, Tenev Tencho, Jaco Isabel, Chen Chih-Hong, Choi Justin, Kasperkiewicz Paulina, Fernandes-Alnemri Teresa, Alnemri Emad, Drag Marcin, Chen Yuan, Meier Pascal
Abstract excerpt
The NLRP3 inflammasome responds to infection and tissue damage, and rapidly escalates the intensity of inflammation by activating interleukin (IL)-1β, IL-18 and cell death by pyroptosis. How the NLRP3 inflammasome is negatively regulated is poorly understood. Here we show that NLRP3 inflammasome activation is suppressed by sumoylation. NLRP3 is sumoylated by the SUMO E3-ligase MAPL, and stimulation-dependent...
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