Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic targets in hematopoietic malignancies.

Oncogene - 29 Sept 2003

Claus Rainer, Lübbert Michael

Abstract excerpt

Frequent genetic alterations in hematopoietic neoplasias (chromosomal translocations, point mutations, etc.) have provided biologic targets for the development of effective novel therapies. A rapidly increasing body of knowledge provides evidence also for multiple epigenetic alterations in these disorders, which can complement or even precede genetic aberrations. Gene inactivation ('silencing') of tumor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dinucleoside Phosphates
Share to DNA Methylation
Share to Gene Silencing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Leukemia, Myeloid

Share to Neoplasms

Share to Point Mutation

Share to Promoter Regions, Genetic

Share to Translocation, Genetic

Source

Identifiers

PMID: 14528273
DOI: 10.1038/sj.onc.1206814

Genes

PML
RARA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic targets in hematopoietic malignancies.PMID 14528273Read ↗

Epigenetic Therapy in Acute Myeloid Leukemia: Current and Future Directions.Semantic proximity Read ↗

DNA Hypermethylation of Myeloid Cells, A Novel Therapeutic Target in MDS and AMLSemantic proximity Read ↗

Review: Recent Clinical Trials in Epigenetic TherapySemantic proximity Read ↗

The epigenetic revolution in hematology: from benchside breakthroughs to clinical transformationsSemantic proximity Read ↗

Targeting DNA Methylation in Leukemia, Myelodysplastic Syndrome, and Lymphoma: A Potential Diagnostic, Prognostic, and Therapeutic ToolSemantic proximity Read ↗

Epigenetics in myeloid malignancies.Semantic proximity Read ↗

Epigenetic Therapy: Histone Acetylation, DNA Methylation and Anti-Cancer Drug DiscoverySemantic proximity Read ↗

Acute myeloid leukemia: therapeutic impact of epigenetic drugs.Semantic proximity Read ↗

Epimutational profile of hematologic malignancies as attractive target for new epigenetic therapiesSemantic proximity Read ↗

Targeting DNA MethylationSemantic proximity Read ↗

Histone deacetylases as therapeutic targets in hematologic malignanciesSemantic proximity Read ↗

The double-edged sword of (re)expression of genes by hypomethylating agents: from viral mimicry to exploitation as priming agents for targeted immune checkpoint modulationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.