Article
Cooperation of Gata3, c-Myc and Notch in malignant transformation of double positive thymocytes.
Molecular immunology - 1 Jun 2008
van Hamburg Jan Piet, de Bruijn Marjolein J W, Dingjan Gemma M, Beverloo H Berna, Diepstraten Hans, Ling Kam-Wing, Hendriks Rudi W
Abstract excerpt
Gata transcription factors are critical regulators of proliferation and differentiation implicated in various human cancers, but specific genes activated by Gata proteins remain to be identified. We previously reported that enforced expression of Gata3 during T cell development in CD2-Gata3 transgenic mice induced CD4(+)CD8(+) double-positive (DP) T cell lymphoma. Here, we show that the presence of the DO11.10...
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