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The prevalence of <i>MADH4</i> and <i>BMPR1A</i> mutations in juvenile polyposis and absence of <i>BMPR2</i>, <i>BMPR1B</i>, and <i>ACVR1</i> mutations

1 Jul 2004

Abstract excerpt

BACKGROUND: Juvenile polyposis (JP) is an autosomal dominant syndrome predisposing to colorectal and gastric cancer. We have identified mutations in two genes causing JP, MADH4 and bone morphogenetic protein receptor 1A (BMPR1A): both are involved in bone morphogenetic protein (BMP) mediated signalling and are members of the TGF-beta superfamily. This study determined the prevalence of mutations in MADH4 and...

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PMID: 15235019
DOI: 10.1136/jmg.2004.018598

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The prevalence of <i>MADH4</i> and <i>BMPR1A</i> mutations in juvenile polyposis and absence of <i>BMPR2</i>, <i>BMPR1B</i>, and <i>ACVR1</i> mutationsPMID 15235019Read ↗

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