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Article

Luminal progenitors restrict their lineage potential during mammary gland development.

PLoS biology - 1 Feb 2015

Rodilla Veronica, Dasti Alessandro, Huyghe Mathilde, Lafkas Daniel, Laurent Cécile, Reyal Fabien, Fre Silvia

Abstract excerpt

The hierarchical relationships between stem cells and progenitors that guide mammary gland morphogenesis are still poorly defined. While multipotent basal stem cells have been found within the myoepithelial compartment, the in vivo lineage potential of luminal progenitors is unclear. Here we used the expression of the Notch1 receptor, previously implicated in mammary gland development and tumorigenesis, to...

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Identifiers

PMID: 25688859
DOI: 10.1371/journal.pbio.1002069
PMCID: PMC4331521

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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