Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Opposing phenotypes in mice with Smith-Magenis deletion and Potocki-Lupski duplication syndromes suggest gene dosage effects on fluid consumption behavior.

American journal of medical genetics. Part A - 1 Nov 2012

Heck Detlef H, Gu Wenli, Cao Ying, Qi Shuhua, Lacaria Melanie, Lupski James R

Abstract excerpt

A quantitative long-term fluid consumption and fluid-licking assay was performed in two mouse models with either an ∼2 Mb genomic deletion, Df(11)17, or the reciprocal duplication copy number variation (CNV), Dp(11)17, analogous to the human genomic rearrangements causing either Smith-Magenis syn...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Abnormalities, Multiple
Share to Behavior, Animal
Share to Chromosome Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosome Duplication

Share to Disease Models, Animal

Share to Drinking

Share to Gene Dosage

Share to Smith-Magenis Syndrome

Source

Open in PubMed Open full text

Identifiers

PMID: 22991245
DOI: 10.1002/ajmg.a.35601
PMCID: PMC3477298

Genes

SMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22991245-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Opposing phenotypes in mice with Smith-Magenis deletion and Potocki-Lupski duplication syndromes suggest gene dosage effects on fluid consumption behavior.PMID 22991245Read ↗

Contrasting behavioral and physiological effects of <i>Gtf2i</i> duplication and deletion in mouse models of the 7q11.23 Duplication and Williams-Beuren SyndromesSemantic proximity Read ↗

Reciprocal Effects on Neurocognitive and Metabolic Phenotypes in Mouse Models of 16p11.2 Deletion and Duplication Syndromes.Semantic proximity Read ↗

Abnormal social behaviors and altered gene expression rates in a mouse model for Potocki-Lupski syndrome.Semantic proximity Read ↗

Duplication of GTF2I results in separation anxiety in mice and humans.Semantic proximity Read ↗

Decreased exploratory activity in a mouse model of 15q duplication syndrome; implications for disturbance of serotonin signaling.Semantic proximity Read ↗

Baicalin ameliorates behavioral and physiological deficits in <i>Gtf2i</i> -duplication mice and modulates synaptic activity in 7q11.23 Duplication Syndrome patient-derived neuronsSemantic proximity Read ↗

Consistent hypersocial behavior in mice carrying a deletion of Gtf2i but no evidence of hyposocial behavior with Gtf2i duplication: Implications for Williams-Beuren syndrome and autism spectrum disorder.Semantic proximity Read ↗

Rai1 duplication causes physical and behavioral phenotypes in a mouse model of dup(17)(p11.2p11.2).Semantic proximity Read ↗

Persistent Feeding and Swallowing Deficits in a Mouse Model of 22q11.2 Deletion SyndromeSemantic proximity Read ↗

Analysis of cerebellar function in Ube3a-deficient mice reveals novel genotype-specific behaviors.Semantic proximity Read ↗

Behavioural abnormalities in a novel mouse model for Silver Russell SyndromeSemantic proximity Read ↗

Genetic control of oromotor phenotypes: A survey of licking and ingestive behaviors in highly diverse strains of mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.