Article
Comparative analyses of time-course gene expression profiles of the long-lived sch9Delta mutant.
Nucleic acids research - 1 Jan 2010
Ge Huanying, Wei Min, Fabrizio Paola, Hu Jia, Cheng Chao, Longo Valter D, Li Lei M
Abstract excerpt
In an attempt to elucidate the underlying longevity-promoting mechanisms of mutants lacking SCH9, which live three times as long as wild type chronologically, we measured their time-course gene expression profiles. We interpreted their expression time differences by statistical inferences based on prior biological knowledge, and identified the following significant changes: (i) between 12 and 24 h, stress...
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