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Article

Orphan G Protein Coupled Receptors in Affective Disorders.

Genes - 24 Jun 2020

Watkins Lyndsay R, Orlandi Cesare

Abstract excerpt

G protein coupled receptors (GPCRs) are the main mediators of signal transduction in the central nervous system. Therefore, it is not surprising that many GPCRs have long been investigated for their role in the development of anxiety and mood disorders, as well as in the mechanism of action of antidepressant therapies. Importantly, the endogenous ligands for a large group of GPCRs have not yet been identified and...

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Identifiers

PMID: 32599826
DOI: 10.3390/genes11060694
PMCID: PMC7349732

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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