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Article

Defective responses to DNA single- and double-strand breaks in spinocerebellar ataxia.

DNA repair - 1 Jul 2008

Lavin Martin F, Gueven Nuri, Grattan-Smith Padraic

Abstract excerpt

Failure to maintain the integrity of DNA/chromatin can result in genome instability and an increased risk of cancer. The description of a number of human genetic disorders characterised not only by cancer predisposition but by a broader phenotype including neurodegeneration suggests that maintaining genome stability is also important for preserving post-mitotic neurons. The identification of genes associated with...

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Identifiers

PMID: 18467193
DOI: 10.1016/j.dnarep.2008.03.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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