Article
Crystal structures of Vibrio harveyi chitinase A complexed with chitooligosaccharides: implications for the catalytic mechanism.
Journal of structural biology - 1 Jun 2008
Songsiriritthigul Chomphunuch, Pantoom Supansa, Aguda Adeleke H, Robinson Robert C, Suginta Wipa
Abstract excerpt
This research describes four X-ray structures of Vibrio harveyi chitinase A and its catalytically inactive mutant (E315M) in the presence and absence of substrates. The overall structure of chitinase A is that of a typical family-18 glycosyl hydrolase comprising three distinct domains: (i) the amino-terminal chitin-binding domain; (ii) the main catalytic (alpha/beta)(8) TIM-barrel domain; and (iii) the small...
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