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Article

Apoptosis-related mitochondrial dysfunction defines human monocyte-derived dendritic cells with impaired immuno-stimulatory capacities.

Journal of cellular and molecular medicine - 1 Jul 2009

Castera Laurent, Hatzfeld-Charbonnier Anne Sophie, Ballot Caroline, Charbonnel Florence, Dhuiege Edith, Velu Thierry, Formstecher Pierre, Mortier Laurent, Marchetti Philippe

Abstract excerpt

The death of dendritic cells (DCs) can potentially influence immune responses by affecting the duration of DC stimulation of lymphocytes. Here, we report that cultured mature monocyte-derived DCs manifest early mitochondrial damage (i.e. within 24 hrs), characterized by mitochondrial membrane potential (psi Delta m) disruption and mitochondrial release of pro-apoptotic factors, followed by reactive oxygen species...

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Identifiers

PMID: 18466357
DOI: 10.1111/j.1582-4934.2008.00358.x
PMCID: PMC4496146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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