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Article

Tumor necrosis factor-α promotes survival and phenotypic maturation of poly(I:C)-treated dendritic cells but impairs their Th1 and Th17 polarizing capability.

Cytotherapy - 1 May 2015

Thorne Ana, Tomić Sergej, Pavlović Bojan, Mihajlović Dušan, Džopalić Tanja, Čolić Miodrag

Abstract excerpt

BACKGROUND AIMS: Toll-like receptor (TLR)-3 synthetic agonist polyinosinic-polycytidylic acid (poly(I:C)) is a promising agent for dendritic cell (DC)-based anti-tumor vaccines because of its ability to induce a strong maturation of DCs, but such an effect is followed by stimulation of DC apoptosis. Tumor necrosis factor (TNF)-α may promote the survival of poly(I:C)-stimulated DCs, but it is not known in detail...

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Identifiers

PMID: 25559144
DOI: 10.1016/j.jcyt.2014.11.006

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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