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The expression of alpha-haemolysin is required for<i>Staphylococcus aureus</i>phagosomal escape after internalization in CFT-1 cells

8 May 2008

Abstract excerpt

Staphylococcus aureus colonizes the lungs of cystic fibrosis patients and treatment with antibiotics usually results in recurrent and relapsing infections. We have shown that S. aureus can invade and replicate within a cystic fibrosis epithelial cell line (CFT-1), and that these internalized bacteria subsequently escape from the endocytic vesicle. The accessory gene regulator, agr, in S. aureus has been shown to...

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PMID: 18466345
DOI: 10.1111/j.1462-5822.2008.01166.x

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