WIPI-1 Positive Autophagosome-Like Vesicles Entrap Pathogenic<i>Staphylococcus aureus</i>for Lysosomal Degradation

Abstract excerpt

Invading pathogens provoke the autophagic machinery and, in a process termed xenophagy, the host cell survives because autophagy is employed as a safeguard for pathogens that escaped phagosomes. However, some pathogens can manipulate the autophagic pathway and replicate within the niche of generated autophagosome-like vesicles. By automated fluorescence-based high content analyses, we demonstrate that...

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