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Article

The Taccalonolides: Microtubule Stabilizers That Circumvent Clinically Relevant Taxane Resistance Mechanisms

30 Oct 2008

Abstract excerpt

The taccalonolides are a class of structurally and mechanistically distinct microtubule-stabilizing agents isolated from Tacca chantrieri. A crucial feature of the taxane family of microtubule stabilizers is their susceptibility to cellular resistance mechanisms including overexpression of P-glycoprotein (Pgp), multidrug resistance protein 7 (MRP7), and the betaIII isotype of tubulin. The ability of four...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18974132
DOI: 10.1158/0008-5472.can-08-2037

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