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Article

A labile point in mutant amphotericin polyketide synthases.

Biotechnology letters - 1 Jun 2011

Khan Naseem, Rawlings Bernard, Caffrey Patrick

Abstract excerpt

Streptomyces nodosus produces the antifungal polyene amphotericin B. Numerous modifications of the amphotericin polyketide synthase have yielded new analogues. However, previous inactivation of the ketoreductase in module 10 resulted in biosynthesis of truncated polyketides. Here we show that modules downstream of this domain remain intact. Therefore, loss of ketoreductase-10 activity is sufficient to cause early...

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Identifiers

PMID: 21267757
DOI: 10.1007/s10529-011-0538-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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