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Article

The extensive and condition-dependent nature of epistasis among whole-genome duplicates in yeast.

Genome research - 1 Jul 2008

Musso Gabriel, Costanzo Michael, Huangfu Manqin, Smith Andrew M, Paw Jadine, San Luis Bryan-Joseph, Boone Charles, Giaever Guri, Nislow Corey, Emili Andrew, Zhang Zhaolei

Abstract excerpt

Since complete redundancy between extant duplicates (paralogs) is evolutionarily unfavorable, some degree of functional congruency is eventually lost. However, in budding yeast, experimental evidence collected for duplicated metabolic enzymes and in global physical interaction surveys had suggested widespread functional overlap between paralogs. While maintained functional overlap is thought to confer robustness...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18463300
DOI: 10.1101/gr.076174.108
PMCID: PMC2493398

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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