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Article

A pals-25 gain-of-function allele triggers systemic resistance against natural pathogens of C. elegans.

PLoS genetics - 1 Oct 2022

Gang Spencer S, Grover Manish, Reddy Kirthi C, Raman Deevya, Chang Ya-Ting, Ekiert Damian C, Barkoulas Michalis, Troemel Emily R

Abstract excerpt

Regulation of immunity throughout an organism is critical for host defense. Previous studies in the nematode Caenorhabditis elegans have described an "ON/OFF" immune switch comprised of the antagonistic paralogs PALS-25 and PALS-22, which regulate resistance against intestinal and epidermal pathogens. Here, we identify and characterize a PALS-25 gain-of-function mutant protein with a premature stop (Q293*), which...

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PMID: 36191002
DOI: 10.1371/journal.pgen.1010314
PMCID: PMC9560605

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