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Article

Role of CYP3A5 in abnormal clearance of methadone.

The Annals of pharmacotherapy - 1 Jun 2008

De Fazio Salvatore, Gallelli Luca, De Siena Antonella, De Sarro Giovambattista, Scordo Maria Gabriella

Abstract excerpt

OBJECTIVE: To report a case of unusually low concentrations of methadone in a polydrug abuser during maintenance treatment with methadone. CASE SUMMARY: A 25-year-old man (weight 55 kg, height 165 cm) with a 12-year history of polydrug abuse was admitted to an opiates withdrawal methadone program. At the time of our observation, he was using both cannabinoids and heroin; no other medical conditions were...

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Share to Analgesics, Opioid
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP3A

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Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 18460585
DOI: 10.1345/aph.1K539

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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