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Article

Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment.

Molecular psychiatry - 1 Dec 2009

Bull S J, Huezo-Diaz P, Binder E B, Cubells J F, Ranjith G, Maddock C, Miyazaki C, Alexander N, Hotopf M, Cleare A J, Norris S, Cassidy E, Aitchison K J, Miller A H, Pariante C M

Abstract excerpt

Depression and fatigue are frequent side effects of interferon-alpha (IFN-alpha) treatment, and there is compelling evidence that the inflammatory response system (including interleukin-6, IL-6) and the serotonergic system is important in the pathophysiology of such symptoms. Functional polymorph...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18458677
DOI: 10.1038/mp.2008.48
PMCID: PMC3513412

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18458677-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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