Article
Population genetic processes affecting the mode of selective sweeps and effective population size in influenza virus H3N2.
BMC evolutionary biology - 3 Aug 2016
Kim Kangchon, Kim Yuseob
Abstract excerpt
BACKGROUND: Human influenza virus A/H3N2 undergoes rapid adaptive evolution in response to host immunity. Positively selected amino acid substitutions have been detected mainly in the hemagglutinin (HA) segment. The genealogical tree of HA sequences sampled over several decades comprises a long trunk and short side branches, which indicates small effective population size. Various studies have reproduced this...
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