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Article

Open field locomotor activity and anxiety-related behaviors in mucopolysaccharidosis type IIIA mice.

Behavioural brain research - 5 Aug 2008

Lau Adeline A, Crawley Allison C, Hopwood John J, Hemsley Kim M

Abstract excerpt

Mucopolysaccharidosis (MPS) IIIA, or Sanfilippo syndrome, is a lysosomal storage disorder characterized by severe and progressive neuropathology. Following an asymptomatic period, patients may present with sleep disturbances, cognitive decline, aggressive tendencies and hyperactivity. A naturally-occurring mouse model of MPS IIIA also exhibits many of these behavioral features and has been recently back-crossed...

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Source

Identifiers

PMID: 18453006
DOI: 10.1016/j.bbr.2008.03.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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