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Article

Development of sensory, motor and behavioral deficits in the murine model of Sanfilippo syndrome type B.

PloS one - 22 Aug 2007

Heldermon Coy D, Hennig Anne K, Ohlemiller Kevin K, Ogilvie Judith M, Herzog Erik D, Breidenbach Annalisa, Vogler Carole, Wozniak David F, Sands Mark S

Abstract excerpt

BACKGROUND: Mucopolysaccharidosis (MPS) IIIB (Sanfilippo Syndrome type B) is caused by a deficiency in the lysosomal enzyme N-acetyl-glucosaminidase (Naglu). Children with MPS IIIB develop disturbances of sleep, activity levels, coordination, vision, hearing, and mental functioning culminating in early death. The murine model of MPS IIIB demonstrates lysosomal distention in multiple tissues, a shortened life...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17712420
DOI: 10.1371/journal.pone.0000772
PMCID: PMC1945015

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ABR
ERG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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