Article
Common MCL1 polymorphisms associated with risk of tuberculosis.
BMB reports - 30 Apr 2008
Shin Hyoung Doo, Cheong Hyun Sub, Park Byung Lae, Kim Lyoung Hyo, Han Chang Su, Lee In Hee, Park Seung Kyu
Abstract excerpt
MCL1 expression has been found to be up-regulated during infection with virulent Mycobacterium tuberculosis. We investigated the genetic polymorphisms in MCL1 as potential candidate gene for a host genetic study of clinical TB infection. We have sequenced exons and their boundaries of MCL1, including the 1.5 kb promoter region, to identify polymorphisms, and eight polymorphisms were identified. The genetic...
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