Article
Laboratory evolution of Pyrococcus furiosus alcohol dehydrogenase to improve the production of (2S,5S)-hexanediol at moderate temperatures.
Extremophiles : life under extreme conditions - 1 Jul 2008
Machielsen Ronnie, Leferink Nicole G H, Hendriks Annemarie, Brouns Stan J J, Hennemann Hans-Georg, Daussmann Thomas, van der Oost John
Abstract excerpt
There is considerable interest in the use of enantioselective alcohol dehydrogenases for the production of enantio- and diastereomerically pure diols, which are important building blocks for pharmaceuticals, agrochemicals and fine chemicals. Due to the need for a stable alcohol dehydrogenase with activity at low-temperature process conditions (30 degrees C) for the production of (2S,5S)-hexanediol, we have...
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