Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of ADAMDEC1 haplotype with high factor VIII levels in venous thromboembolism.

Thrombosis and haemostasis - 1 May 2008

Berger Mario, Moscatelli Henriette, Kulle Bettina, Luxembourg Beate, Blouin Katja, Spannagl Michael, Lindhoff-Last Edelgard, Schambeck Christian M

Abstract excerpt

A suggestive locus on chromosome 8 could be shown to be associated with familial high factor VIII (FVIII) levels in venous thromboembolism. The ADAMDEC 1 gene is a candidate expressing an ectodomain sheddase. However, the ectodomain of the clearance receptor for FVIII, the low-density lipoprotein receptor-related protein (LRP), is subject to proteolysis by metalloproteases like ADAMDEC1. Other LRP-interacting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADAM Proteins
Share to Factor VIII

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germany

Share to Lipoprotein Lipase

Share to Metalloendopeptidases

Share to Registries

Share to Tissue Plasminogen Activator

Share to Venous Thromboembolism

Source

Identifiers

PMID: 18449420
DOI: 10.1160/TH08-01-0059

Genes

ADAMDEC1
LPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of ADAMDEC1 haplotype with high factor VIII levels in venous thromboembolism.PMID 18449420Read ↗

Role of ADAMTS13, VWF and F8 genes in deep vein thrombosis.Semantic proximity Read ↗

Polymorphisms and mutations in vWF and ADAMTS13 genes and their correlation with plasma levels of FVIII and vWF in patients with deep venous thrombosis.Semantic proximity Read ↗

Genetic variations in sites of affinity between FVIII and LRP1 are not associated with high FVIII levels in venous thromboembolism.Semantic proximity Read ↗

Coagulation factor V G allele and HR2 haplotype: factor V activity, activated protein C resistance and risk of venous thrombosis.Semantic proximity Read ↗

Polymorphisms in some proinflammatory genes (TNFα and β, IL-1β, IL-6, ADAM17) in severe chronic venous disease.Semantic proximity Read ↗

P-selectin gene haplotypes modulate soluble P-selectin concentrations and contribute to the risk of venous thromboembolism.Semantic proximity Read ↗

Haplotypes encoding the factor VIII 1241 Glu variation, factor VIII levels and the risk of venous thrombosis.Semantic proximity Read ↗

Partial F8 gene duplication (factor VIII Padua) associated with high factor VIII levels and familial thrombophilia.Semantic proximity Read ↗

Protective effect of a thrombin receptor (protease-activated receptor 1) gene polymorphism toward venous thromboembolism.Semantic proximity Read ↗

Copy number variations of the F8 gene are associated with venous thromboembolism.Semantic proximity Read ↗

A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis.Semantic proximity Read ↗

A case control study of deep venous thrombosis in relation to factor V G1691A (Leiden) and A4070G (HR2 Haplotype) polymorphisms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.