Article
Polymorphisms and mutations in vWF and ADAMTS13 genes and their correlation with plasma levels of FVIII and vWF in patients with deep venous thrombosis.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis - 1 Oct 2011
Bittar Luis Fernando, de Paula Erich Vinícius, Mello Tayana B T, Siqueira Lúcia H, Orsi Fernanda L A, Annichino-Bizzacchi Joyce M
Abstract excerpt
BACKGROUND: Increased levels of factor VIII (FVIII) are a prevalent and independent risk factor for deep venous thrombosis (DVT) and are affected by von Willebrand factor (vWF) levels. DESIGN AND METHODS: ADAMTS13 contributes to vWF levels, and we investigated genetic polymorphisms previously described to be associated with decreased levels of these proteins in 435 patients with DVT (126 M and 309 F; median age...
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