Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variations in sites of affinity between FVIII and LRP1 are not associated with high FVIII levels in venous thromboembolism.

Scientific reports - 18 Mar 2015

Bittar Luis F, Siqueira Lucia H, Orsi Fernanda A, De Paula Erich V, Annichino-Bizzacchi Joyce M

Abstract excerpt

Increased factor VIII (FVIII) levels are a prevalent and independent risk factor for venous thromboembolism (VTE). The low density lipoprotein receptor-related protein 1 (LRP1) has been associated with FVIII catabolism. After a median of 10 years of the first thrombotic episode, we evaluated FVIII activity levels in 75 patients with VTE and high FVIII levels and in 74 healthy controls. Subsequently, we evaluated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Exons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Factor VIII

Share to Follow-Up Studies

Share to Introns

Share to Low Density Lipoprotein Receptor-Related Protein-1

Share to Protein Binding

Share to Venous Thromboembolism

Source

Open in PubMed Open full text

Identifiers

PMID: 25782371
DOI: 10.1038/srep09246
PMCID: PMC4363825

Genes

LRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variations in sites of affinity between FVIII and LRP1 are not associated with high FVIII levels in venous thromboembolism.PMID 25782371Read ↗

Low-density lipoprotein receptor-related protein 1 polymorphism 663 C > T affects clotting factor VIII activity and increases the risk of venous thromboembolism.Semantic proximity Read ↗

Haplotypes encoding the factor VIII 1241 Glu variation, factor VIII levels and the risk of venous thrombosis.Semantic proximity Read ↗

Association of ADAMDEC1 haplotype with high factor VIII levels in venous thromboembolism.Semantic proximity Read ↗

Is there any correlation between the elevated plasma levels and gene variations of factor VIII in Turkish thrombosis patients?Semantic proximity Read ↗

The factor VIII D1241E polymorphism is associated with decreased factor VIII activity and not with activated protein C resistance levels.Semantic proximity Read ↗

The role of plasminogen activator inhibitor-1 polymorphism, factor-V-Leiden, and prothrombin-20210 mutations in pulmonary thromboembolism.Semantic proximity Read ↗

Marburg I polymorphism of factor VII-activating protease and risk of recurrent venous thromboembolism.Semantic proximity Read ↗

Partial F8 gene duplication (factor VIII Padua) associated with high factor VIII levels and familial thrombophilia.Semantic proximity Read ↗

Determination of vWF, ADAMTS-13 and Thrombospondin-1 in Venous Thromboembolism and Relating Them to the Presence of Factor V Leiden Mutation.Semantic proximity Read ↗

Copy number variations of the F8 gene are associated with venous thromboembolism.Semantic proximity Read ↗

A common polymorphism decreases LRP1 mRNA stability and is associated with increased plasma factor VIII levels.Semantic proximity Read ↗

Parameters influencing FVIII pharmacokinetics in patients with severe and moderate haemophilia A.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.