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Article

High diversification of CD94 by alternative splicing in New World primates.

Immunogenetics - 1 Apr 2013

Galindo John A, Cadavid Luis F

Abstract excerpt

CD94 forms heterodimers with NKG2A, -C, or -E to constitute lectin-like natural killer cell receptors for MHC-E. Its structure differs from other C-type lectins in that the second α-helix is replaced by a loop that forms the interacting interface with the NKG2 molecules. Although CD94 has remained highly conserved mammals, several alternative splicing variants have been detected in some species. To evaluate the...

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PMID: 23370862
DOI: 10.1007/s00251-013-0685-x

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