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Article

Human NKG2E is expressed and forms an intracytoplasmic complex with CD94 and DAP12.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2014

Orbelyan Gerasim A, Tang Fangming, Sally Benjamin, Solus Jason, Meresse Bertrand, Ciszewski Cezary, Grenier Jean-Christophe, Barreiro Luis B, Lanier Lewis L, Jabri Bana

Abstract excerpt

The NKG2 family of NK receptors includes activating and inhibitory members. With the exception of the homodimer-forming NKG2D, NKG2 receptors recognize the nonclassical MHC class I molecule HLA-E, and they can be subdivided into two groups: those that associate with and signal through DAP12 to activate cells, and those that contain an ITIM motif to promote inhibition. The function of NKG2 family member NKG2E is...

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Identifiers

PMID: 24935923
DOI: 10.4049/jimmunol.1400556
PMCID: PMC4091631

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