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Article

High grade prostatic intraepithelial neoplasia does not display loss of heterozygosity at the mutation locus in BRCA2 mutation carriers with aggressive prostate cancer.

BJU international - 1 Dec 2012

Willems-Jones Amber, Kavanagh Liam, Clouston David, Bolton Damien, Fox Stephen, Thorne Heather

Abstract excerpt

UNLABELLED: What's known on the subject? and What does the study add? The risk of developing aggressive prostate cancer is increased for men carrying a pathogenic germline mutation in BRCA2. An earlier study by the Kathleen Cuningham Consortium for Research into Familial Breast Cancer showed that BRCA2 mutation carriers displayed a loss of heterozygosity (LOH) within their prostate cancer tissue in the majority...

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Source

Identifiers

PMID: 23035815
DOI: 10.1111/j.1464-410X.2012.11519.x

Genes

BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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